ICAM1 靶点信息

ICAM1 分子靶点信息概述

  • 分子名：ICAM1, intercellular adhesion molecule 1
  • 基因家族：CD molecules; Receptor ligands; Immunoglobulin like domain containing; Ig-like cell adhesion molecule family
  • 别名：BB2; CD54
  • 全称：human rhinovirus receptor

ICAM1 分子靶点综述

细胞间粘附分子1(ICAM-1)也称为CD54，是一个几乎无所不在的跨膜糖蛋白，通常表达于内皮细胞和免疫细胞，对白细胞迁移和活化具有关键作用。它与CD11a/CD18或CD11b/CD18型整合素结合，也会被鼻病毒作为受体利用。可溶性细胞间粘附分子1(sICAM-1)促进血管生成，可作为血管内皮细胞活化或受损的指示剂。它也可作为跨膜ICAM-1抑制剂，介导活性如单核细胞对活化的内皮细胞的黏附以及肿瘤细胞对NK细胞介导的溶解作用的敏感性。监测血清中的sICAM-1表达水平可对多种病理状态提供更加详细的视角，如心血管疾病、II型糖尿病、器官移植障碍、氧化应激、腹部脂肪团、高血压、肝脏疾病和某些恶性肿瘤等。

ICAM1, intercellular adhesion molecule 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ICAM1 分子靶点信息

  • 分子名：ICAM1, intercellular adhesion molecule 1
  • 别称：
    • BB2
    • CD54
    • cell surface glycoprotein P3.58
    • human rhinovirus receptor
    • ICAM-1
    • intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
    • major group rhinovirus receptor
    • P3.58
  • 基因序列：NCBI_Gene: 3383
  • 蛋白序列：UniProtKB: P05362

人 Human ICAM1靶点分子功能（预测）

Enables integrin binding activity. Involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; cellular response to amyloid-beta; and negative regulation of apoptotic process. Located in extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); and lung disease (multiple).

小鼠 Mouse Icam1 分子靶点信息

小鼠 Mouse Icam1 靶点分子功能（预测）

Predicted to enable integrin binding activity. Acts upstream of or within several processes, including T cell antigen processing and presentation; cellular response to glucose stimulus; and cellular response to leukemia inhibitory factor. Located in external side of plasma membrane and immunological synapse. Colocalizes with membrane raft. Is expressed in several structures, including cardiovascular system; liver vasculature; lung; skin; and thymus primordium. Used to study malaria. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; inflammatory bowel disease (multiple); liver cirrhosis; and uveitis (multiple). Orthologous to human ICAM1 (intercellular adhesion molecule 1).

大鼠 Rat Icam1 分子靶点信息

大鼠 Rat Icam1 靶点分子功能（预测）

Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1).

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