HGF 靶点信息

HGF 分子靶点信息概述

  • 分子名：HGF, hepatocyte growth factor
  • 别名：SF; F-TCF; HGFB; HPTA
  • 曾用名：DFNB39
  • 全称：hepatopoietin A; fibroblast-derived tumor cytotoxic factor; scatter factor; lung fibroblast-derived mitogen; deafness, autosomal recessive 39; hepatocyte growth factor (hepapoietin A; scatter factor)

HGF 分子靶点综述

肝细胞生长因子(HGF)是旁分泌性细胞生长、运动和形态发生的因子，由间充质细胞分泌产生，可作为大部分上皮来源细胞的多功能细胞因子。HGF以单链形式存在，是一个带有29个氨基酸信号序列和25个氨基酸前体序列的728个氨基酸残基前肽。HGF结合原癌基因c-Met受体后就会激活酪氨酸激酶信号级联，进而调节细胞的生长、运动和形态发生。它在血管生成、肿瘤发生和组织再生中起核心作用。目前正在测试人HGF质粒DNA治疗心肌细胞是否可作为冠状动脉疾病和心肌梗死后心脏损伤的一种潜在治疗。HGF也可作为基孔肯雅病毒诱导的关节痛的预后指示。高水平的HGF与与快速康复有关。

HGF, hepatocyte growth factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human HGF 分子靶点信息

  • 分子名：HGF, hepatocyte growth factor
  • 别称：
    • deafness, autosomal recessive 39
    • DFNB39
    • F-TCF
    • fibroblast-derived tumor cytotoxic factor
    • hepatocyte growth factor (hepapoietin A, scatter factor)
    • hepatopoeitin-A
    • hepatopoietin-A
    • HGFB
    • HPTA
    • lung fibroblast-derived mitogen
    • SF
  • 基因序列：NCBI_Gene: 3082
  • 蛋白序列：UniProtKB: P14210

人 Human HGF靶点分子功能（预测）

Enables chemoattractant activity and identical protein binding activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of programmed cell death; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in membrane. Implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Biomarker of several diseases, including artery disease (multiple); biliary tract disease (multiple); myositis (multiple); retinal disease (multiple); and rheumatoid arthritis (multiple).

小鼠 Mouse Hgf 分子靶点信息

小鼠 Mouse Hgf 靶点分子功能（预测）

Predicted to enable chemoattractant activity; growth factor activity; and identical protein binding activity. Acts upstream of or within several processes, including regulation of MAPK cascade; regulation of cytokine production; and regulation of protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; embryo mesenchyme; and genitourinary system. Used to study autosomal recessive nonsyndromic deafness 39 and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).

大鼠 Rat Hgf 分子靶点信息

  • 分子名：Hgf, hepatocyte growth factor
  • 别称：
    • hepatocyte growth factor (scatter factor)
    • hepatopoeitin-A
    • hepatopoietin-A
    • HPTA
    • scatter factor
    • SF
  • 基因序列：NCBI_Gene: 24446
  • 蛋白序列：UniProtKB: P17945

大鼠 Rat Hgf 靶点分子功能（预测）

Enables growth factor activity. Involved in several processes, including animal organ regeneration; positive regulation of angiogenesis; and positive regulation of myelination. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).

HGF 分子产品列表

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