FLT1 靶点信息

FLT1 分子靶点信息概述

  • 分子名：FLT1, fms related receptor tyrosine kinase 1
  • 基因家族：Receptor tyrosine kinases; I-set domain containing
  • 别名：VEGFR1
  • 曾用名：FLT
  • 全称：vascular endothelial growth factor receptor 1; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); fms-related tyrosine kinase 1; fms related tyrosine kinase 1

FLT1 分子靶点综述

血管内皮生长因子受体1(VEGF R1)也称为Flt-1，是血管生成因子VEGF (VEGF-A)、胎盘生长因子(PIGF)和VEGF-B的特异性酪氨酸激酶 (RTK) 受体。根据剪切形式，存在膜型 (mbVEGFR)和可溶性(sVEGFR) 两种形式。实验和临床上注射sVEGF R1成功地阻止了血管新生和肿瘤生长。在不同的病理条件下，血清/血浆中的sVEGF R1含量有所不同，可能具有诊断价值。在实验和病理条件下，sVEGF R1和VEGF水平相关。在孕妇和原发性高血压患者的血浆中存在高水平的sVEGF R1。心血管疾病患者和吸烟者的血浆中，sVEGF R1水平显著降低。

FLT1, fms related receptor tyrosine kinase 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FLT1 分子靶点信息

  • 分子名：FLT1, fms related receptor tyrosine kinase 1
  • 别称：
    • FLT
    • FLT-1
    • fms related tyrosine kinase 1
    • fms-like tyrosine kinase 1
    • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
    • tyrosine-protein kinase FRT
    • tyrosine-protein kinase receptor FLT
    • vascular endothelial growth factor receptor 1
    • vascular permeability factor receptor
    • VEGFR-1
    • VEGFR1
  • 基因序列：NCBI_Gene: 2321
  • 蛋白序列：UniProtKB: P17948

人 Human FLT1靶点分子功能（预测）

Enables growth factor binding activity; placental growth factor-activated receptor activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including monocyte chemotaxis; positive regulation of kinase activity; and protein phosphorylation. Located in actin cytoskeleton and plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Biomarker of several diseases, including Kawasaki disease; Leydig cell tumor; cerebrovascular disease (multiple); kidney cancer (multiple); and retinal disease (multiple).

小鼠 Mouse Flt1 分子靶点信息

小鼠 Mouse Flt1 靶点分子功能（预测）

Enables identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).

大鼠 Rat Flt1 分子靶点信息

  • 分子名：Flt1, Fms related receptor tyrosine kinase 1
  • 别称：
    • FLT-1
    • FMS-like tyrosine kinase 1
    • FMS-related tyrosine kinase 1
    • Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
    • LOC100911280
    • tyrosine-protein kinase receptor FLT
    • vascular endothelial growth factor receptor 1
    • vascular endothelial growth factor receptor 1-like
    • vascular endothelial growth factor/vascular permeability factor receptor
    • VEGFR-1
  • 基因序列：NCBI_Gene: 54251
  • 蛋白序列：

大鼠 Rat Flt1 靶点分子功能（预测）

Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).

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