ENG 分子靶点信息 - ENG分子别称 | 人/小鼠/大鼠ENG分子靶点功能 | ENG分子靶点检测

文章目录[隐藏]

ENG 分子靶点信息概述
ENG 分子靶点综述
ENG, endoglin 分子靶点种属信息
ENG 分子产品列表
Anti-Human CD105, APC (Clone: 00244) 检测试剂
Anti-Human CD105, PE (Clone: 00244) 检测试剂
Mouse Endoglin/CD105 ELISA Kit检测试剂盒（酶联免疫吸附法）
Mouse Endoglin/CD105 Standard (小鼠内皮糖蛋白标准品)
Human Endoglin/CD105 ELISA Kit检测试剂盒（酶联免疫吸附法）
Human Endoglin/CD105 Standard (人内皮糖蛋白标准品)
ENG 分子靶点最新资讯

ENG 分子靶点信息概述

分子名：ENG, endoglin
基因家族：CD molecules
别名：END; HHT1; CD105
曾用名：ORW1; ORW
全称：Osler-Rendu-Weber syndrome 1

ENG 分子靶点综述

内皮糖蛋白(Endoglin)，又称为CD105，是位于细胞膜表面的I型跨膜糖蛋白，是TGF-β受体复合物之一。它参与调控与TGF-β1、TGF-β3、Activin-A、BMP-2和BMP-7结合的应答。Endoglin被推测参与影响细胞形态和迁移的细胞骨架构成。它在心血管系统发育和血管重塑中发挥作用。在心脏发育过程中，Endoglin的表达受到调控。缺失Endoglin基因的实验小鼠由于心血管异常而死亡。在人类中，Endoglin可能参与常染色体显性疾病，为人熟知的是1型遗传性出血性毛细血管扩张症(HHT)。它会导致频繁的鼻出血、皮肤和粘膜毛细管扩张，在不同的器官(如大脑、肺和肝脏)中引起动静脉畸形。

ENG, endoglin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ENG 分子靶点信息

分子名：ENG, endoglin
别称：
- CD105
- CD105 antigen
- END
- FLJ41744
- HHT1
- ORW
- ORW1
基因序列：NCBI_Gene: 2022
蛋白序列：UniProtKB: P17813

人 Human ENG靶点分子功能（预测）

Enables several functions, including galactose binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Contributes to BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including central nervous system vasculogenesis; regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in external side of plasma membrane; extracellular space; and nuclear body. Part of receptor complex. Implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Biomarker of several diseases, including artery disease (multiple); clear cell renal cell carcinoma; diabetic retinopathy; hematologic cancer (multiple); and secondary hyperparathyroidism.

小鼠 Mouse Eng 分子靶点信息

分子名：Eng, endoglin
别称：
- AI528660
- AI662476
- CD105
- Endo
- expressed sequence AI528660
- expressed sequence AI662476
基因序列：NCBI_Gene: 13805
蛋白序列：

小鼠 Mouse Eng 靶点分子功能（预测）

Enables protein homodimerization activity and transforming growth factor beta binding activity. Involved in several processes, including circulatory system development; positive regulation of cell differentiation; and regulation of gene expression. Acts upstream of or within circulatory system development and positive regulation of angiogenesis. Located in endothelial microparticle. Is expressed in several structures, including brain; cardiovascular system; extraembryonic vascular system; and lung. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin).

大鼠 Rat Eng 分子靶点信息

分子名：Eng, endoglin
别称：
- MGC124909
基因序列：NCBI_Gene: 497010
蛋白序列：

大鼠 Rat Eng 靶点分子功能（预测）

Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin).