CD55 靶点信息

CD55 分子靶点信息概述

  • 分子名：CD55, CD55 molecule (Cromer blood group)
  • 基因家族：Blood group antigens; CD molecules; Sushi domain containing; Complement system regulators and receptors
  • 别名：CR; TC; CROM
  • 曾用名：DAF
  • 全称：decay accelerating factor for complement (CD55, Cromer blood group system); CD55 molecule, decay accelerating factor for complement (Cromer blood group)

CD55 分子靶点综述

CD55 是一种 60-70kD 的糖基磷脂酰肌醇(GPI)固定单链糖蛋白，又称衰变加速因子(DAF)。它表达于造血细胞，包括红细胞和许多非造血细胞。CD55 可降低 NK 细胞裂解效率，诱导 T 细胞信号转导。CD55 还被证明与 CD97 相互作用，并与柯萨奇和呼肠孤病毒结合。

CD55, CD55 molecule (Cromer blood group) 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD55 分子靶点信息

  • 分子名：CD55, CD55 molecule (Cromer blood group)
  • 别称：
    • CD55 antigen
    • CD55 molecule, decay accelerating factor for complement (Cromer blood group)
    • CHAPLE
    • complement decay-accelerating factor
    • CR
    • CROM
    • Cromer blood group antigen
    • DAF
    • decay accelerating factor for complement
    • Rh blood group D antigen
    • TC
  • 基因序列：NCBI_Gene: 1604
  • 蛋白序列：UniProtKB: P08174

人 Human CD55靶点分子功能（预测）

Enables lipid binding activity and virus receptor activity. Involved in several processes, including positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell cytokine production; and regulation of lipopolysaccharide-mediated signaling pathway. Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Located in cell surface; membrane raft; and plasma membrane. Implicated in prostate cancer and protein-losing enteropathy. Biomarker of breast cancer; cervical cancer; and endometrial adenocarcinoma.

小鼠 Mouse Cd55 分子靶点信息

小鼠 Mouse Cd55 靶点分子功能（预测）

Predicted to enable enzyme inhibitor activity; lipid binding activity; and virus receptor activity. Acts upstream of or within regulation of complement activation, classical pathway. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)).

大鼠 Rat Cd55 分子靶点信息

  • 分子名：Cd55, CD55 molecule (Cromer blood group)
  • 别称：
    • CD55 antigen
    • CD55 molecule, decay accelerating factor for complement
    • complement decay-accelerating factor
    • Daf
    • Daf1
    • decay accelarating factor 1
    • decay accelerating factor 1
    • decay accelerating factor GPI-form
    • decay-accelarating factor
    • glycosylphophatidylinositol-anchored form
  • 基因序列：NCBI_Gene: 64036
  • 蛋白序列：

大鼠 Rat Cd55 靶点分子功能（预测）

Enables enzyme inhibitor activity. Involved in several processes, including maternal process involved in parturition; negative regulation of complement activation; and spermatogenesis. Located in apical plasma membrane. Used to study neuroblastoma and proteinuria. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)).

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