CST3 靶点信息

CST3 分子靶点信息概述

  • 分子名：CST3, cystatin C
  • 基因家族：Cystatins, type 2
  • 全称：cystatin C (amyloid angiopathy and cerebral hemorrhage)

CST3 分子靶点综述

半胱氨酸蛋白酶抑制剂C属于半胱氨酸蛋白酶抑制剂超家族，是溶酶体蛋白酶的有效抑制剂，可能是半胱氨酸蛋白酶最重要的胞外抑制剂之一。它几乎存在于所有组织和体液中，包括血浆、尿液和脑脊液。Cystatin C通过调节半胱氨酸蛋白酶活性参与多种疾病过程。Cystatin C主要作为肾功能的生物标志物。最近，研究显示它在预测新发或恶化的心血管疾病中起作用。另外，它在淀粉样蛋白有关的脑疾病如阿尔茨海默氏病中发挥作用。

CST3, cystatin C 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CST3 分子靶点信息

  • 分子名：CST3, cystatin C
  • 别称：
    • ARMD11
    • bA218C14.4 (cystatin C)
    • cystatin 3
    • cystatin C (amyloid angiopathy and cerebral hemorrhage)
    • cystatin-3
    • cystatin-C
    • epididymis secretory protein Li 2
    • gamma-trace
    • HEL-S-2
    • MGC117328
    • neuroendocrine basic polypeptide
    • post-gamma-globulin
  • 基因序列：NCBI_Gene: 1471
  • 蛋白序列：UniProtKB: P01034

人 Human CST3靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; cysteine-type endopeptidase inhibitor activity; and identical protein binding activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of catabolic process; and negative regulation of extracellular matrix disassembly. Located in Golgi apparatus; extracellular space; and plasma membrane. Implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of the nervous system (multiple); brain ischemia; obesity; and type 2 diabetes mellitus.

小鼠 Mouse Cst3 分子靶点信息

小鼠 Mouse Cst3 靶点分子功能（预测）

Predicted to enable several functions, including amyloid-beta binding activity; cysteine-type endopeptidase inhibitor activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of cell death; positive regulation of DNA replication; and response to oxidative stress. Predicted to act upstream of or within negative regulation of peptidase activity. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system; early conceptus; heart; reproductive system; and visual system. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (cystatin C).

大鼠 Rat Cst3 分子靶点信息

  • 分子名：Cst3, cystatin C
  • 别称：
    • CYSC
    • cystatin 3
    • Cystatin C (cysteine proteinase inhibitor)
    • cystatin-3
    • cystatin-C
    • MGC105556
  • 基因序列：NCBI_Gene: 25307
  • 蛋白序列：UniProtKB: P14841

大鼠 Rat Cst3 靶点分子功能（预测）

Enables peptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ development; circadian sleep/wake cycle, REM sleep; and embryo implantation. Located in several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (cystatin C).

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