CSF2 靶点信息

CSF2 分子靶点信息概述

  • 分子名：CSF2, colony stimulating factor 2
  • 别名：GM-CSF; GMCSF
  • 全称：sargramostim; molgramostim; granulocyte-macrophage colony stimulating factor; colony stimulating factor 2 (granulocyte-macrophage)

CSF2 分子靶点综述

粒细胞-巨噬细胞集落刺激因子(GM-CSF)是一种调节白细胞生长的细胞因子。GM-CSF刺激干细胞产生粒细胞(中性粒细胞、嗜酸性粒细胞和嗜碱性粒细胞)及单核细胞。此外，它对造血和非造血谱系细胞也具有活性。GM-CSF用作药物来刺激白细胞的产生，从而预防化疗后引起的中性粒细胞减少症。近来，人们正在临床试验评估GM-CSF作为一种潜在的疫苗佐剂对HIV感染患者的疗效。相关研究报道一些癌症(包括肺癌和急性髓细胞白血病)患者的血清中具有较高水平的GM-CSF，同样在支气管哮喘患者外周血和鳞屑提取物中也具有较高水平的GM-CSF。

CSF2, colony stimulating factor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CSF2 分子靶点信息

  • 分子名：CSF2, colony stimulating factor 2
  • 别称：
    • colony stimulating factor 2 (granulocyte-macrophage)
    • colony-stimulating factor
    • CSF
    • GMCSF
    • granulocyte macrophage-colony stimulating factor
    • granulocyte-macrophage colony stimulating factor
    • granulocyte-macrophage colony-stimulating factor
    • MGC131935
    • MGC138897
    • molgramostim
    • molgramostin
    • sargramostim
  • 基因序列：NCBI_Gene: 1437
  • 蛋白序列：UniProtKB: P04141

人 Human CSF2靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including cellular response to granulocyte macrophage colony-stimulating factor stimulus; myeloid leukocyte differentiation; and positive regulation of macromolecule metabolic process. Located in extracellular space and intracellular membrane-bounded organelle. Implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Biomarker of COVID-19; asthma; chronic obstructive pulmonary disease; and temporal arteritis.

小鼠 Mouse Csf2 分子靶点信息

小鼠 Mouse Csf2 靶点分子功能（预测）

Enables cytokine activity. Acts upstream of or within several processes, including embryonic placenta development; myeloid leukocyte differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including genitourinary system; hemolymphoid system; labyrinthine zone; liver; and lung. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2).

大鼠 Rat Csf2 分子靶点信息

  • 分子名：Csf2, colony stimulating factor 2
  • 别称：
    • colony stimulating factor 2 (granulocyte-macrophage)
    • colony-stimulating factor
    • CSF
    • Gm-csf
    • Gmcsf
    • granulocyte-macrophage colony-stimulating factor
  • 基因序列：NCBI_Gene: 116630
  • 蛋白序列：UniProtKB: P48750

大鼠 Rat Csf2 靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including cellular response to lipopolysaccharide; macrophage activation; and response to silicon dioxide. Located in extracellular space. Used to study Parkinsonism and myocardial infarction. Biomarker of abdominal aortic aneurysm; interstitial cystitis; and lung disease (multiple). Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2).

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