CDH3 靶点信息

CDH3 分子靶点信息概述

  • 分子名：CDH3, cadherin 3
  • 基因家族：Type I classical cadherins
  • 别名：CDHP; PCAD
  • 全称：P-cadherin; cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental)

CDH3 分子靶点综述

钙黏蛋白超家族包括许多含有一个或多个钙黏蛋白重复序列的细胞表面糖蛋白，这些蛋白与钙离子依赖性细胞粘附有关。胎盘钙黏蛋白(P-钙黏蛋白)是钙依赖性粘附分子，表达于胎盘、表皮和乳腺。它对于组织、细胞的形态发生、生长和分化具有重要作用，在调节形态发生和维持成人组织结构完整性与极性方面发挥举足轻重的作用。此外，它对肿瘤细胞的浸润也有重大意义。

CDH3, cadherin 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CDH3 分子靶点信息

  • 分子名：CDH3, cadherin 3
  • 别称：
    • cadherin 3, type 1, P-cadherin (placental)
    • cadherin-3
    • calcium-dependent adhesion protein, placental
    • CDHP
    • HJMD
    • PCAD
  • 基因序列：NCBI_Gene: 1001
  • 蛋白序列：UniProtKB: P22223

人 Human CDH3靶点分子功能（预测）

Predicted to enable cadherin binding activity and calcium ion binding activity. Involved in several processes, including negative regulation of timing of catagen; positive regulation of signal transduction; and regulation of gene expression. Located in cell junction and plasma membrane. Implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome.

小鼠 Mouse Cdh3 分子靶点信息

小鼠 Mouse Cdh3 靶点分子功能（预测）

Predicted to enable cadherin binding activity and calcium ion binding activity. Acts upstream of or within cell-cell adhesion. Located in adherens junction and plasma membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3).

大鼠 Rat Cdh3 分子靶点信息

大鼠 Rat Cdh3 靶点分子功能（预测）

Predicted to enable cadherin binding activity and calcium ion binding activity. Involved in response to xenobiotic stimulus and wound healing. Located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3).

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