CD38 靶点信息

CD38 分子靶点信息概述

  • 分子名：CD38, CD38 molecule
  • 基因家族：CD molecules
  • 全称：ADP-ribosyl cyclase 1; NAD(+) nucleosidase; CD38 antigen (p45)

CD38 分子靶点综述

CD38是一个定位于膜上的糖蛋白，催化环腺苷二磷酸核糖的合成和降解，参与细胞粘附和信号转导。CD31是CD38的配体，当两者结合时，可导致骨髓B细胞凋亡，但可阻止扁桃体B细胞的凋亡，促进脾脏B细胞的增殖。正常表达于胸腺细胞、早期B和T细胞、生发中心B细胞、部分T细胞等。异常表达于骨髓瘤细胞、原发性渗出性淋巴瘤、一些慢性淋巴细胞白血病。

CD38, CD38 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD38 分子靶点信息

  • 分子名：CD38, CD38 molecule
  • 别称：
    • 2'-phospho-ADP-ribosyl cyclase
    • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
    • 2'-phospho-cyclic-ADP-ribose transferase
    • ADP-ribosyl cyclase 1
    • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
    • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    • ADPRC 1
    • ADPRC1
    • cADPr hydrolase 1
    • cd38 antigen
    • CD38 antigen (p45)
    • cluster of differentiation 38
    • cyclic ADP-ribose hydrolase 1
    • ecto-nicotinamide adenine dinucleotide glycohydrolase
    • NAD(+) nucleosidase
    • T10
  • 基因序列：NCBI_Gene: 952
  • 蛋白序列：UniProtKB: P28907

人 Human CD38靶点分子功能（预测）

Predicted to enable NAD+ nucleosidase activity and phosphorus-oxygen lyase activity. Involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and regulation of transcription, DNA-templated. Located in plasma membrane. Implicated in type 1 diabetes mellitus and type 2 diabetes mellitus.

小鼠 Mouse Cd38 分子靶点信息

小鼠 Mouse Cd38 靶点分子功能（预测）

Enables hydrolase activity, acting on glycosyl bonds; identical protein binding activity; and phosphorus-oxygen lyase activity. Acts upstream of or within positive regulation of B cell proliferation. Located in cell surface and membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule).

大鼠 Rat Cd38 分子靶点信息

  • 分子名：Cd38, CD38 molecule
  • 别称：
    • 2'-phospho-ADP-ribosyl cyclase
    • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
    • 2'-phospho-cyclic-ADP-ribose transferase
    • ADP-ribosyl cyclase 1
    • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    • ADPRC 1
    • cADPr hydrolase 1
    • CD38 antigen
    • CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)
    • CD38H
    • cyclic ADP-ribose hydrolase 1
  • 基因序列：NCBI_Gene: 25668
  • 蛋白序列：UniProtKB: Q64244

大鼠 Rat Cd38 靶点分子功能（预测）

Enables NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule).

CD38 分子产品列表

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