BMP6 靶点信息

BMP6 分子靶点信息概述

  • 分子名：BMP6, bone morphogenetic protein 6
  • 基因家族：Bone morphogenetic proteins
  • 别名：VGR1
  • 曾用名：VGR
  • 全称：vegetal related growth factor (TGFB-related)

BMP6 分子靶点综述

骨形态发生蛋白6 (BMP-6)，由BMP6基因编码，是TGF-β超家族中的一员。骨形态发生蛋白可诱导骨和软骨的生长。BMP-6可诱导间充质干细胞中所有成骨细胞的标记，2009年的《自然遗传学》杂志上描述了BMP-6的另一功能，它是铁调素的关键调控子，后者是由哺乳动物铁代谢的主要调节者肝脏所分泌的小分子肽。

BMP6, bone morphogenetic protein 6 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human BMP6 分子靶点信息

  • 分子名：BMP6, bone morphogenetic protein 6
  • 别称：
    • BMP-6
    • vegetal related growth factor (TGFB-related)
    • vegetal-related (TGFB related) cytokine
    • VG-1-R
    • VG-1-related protein
    • Vg1-related sequence
    • VGR
    • VGR-1
    • VGR1
  • 基因序列：NCBI_Gene: 654
  • 蛋白序列：UniProtKB: P22004

人 Human BMP6靶点分子功能（预测）

Enables BMP receptor binding activity and protein heterodimerization activity. Involved in several processes, including negative regulation of adherens junction organization; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in cytoplasm and vesicle. Predicted to be active in extracellular space. Biomarker of breast cancer; esophagus squamous cell carcinoma; prostate cancer; and renal cell carcinoma.

小鼠 Mouse Bmp6 分子靶点信息

小鼠 Mouse Bmp6 靶点分子功能（预测）

Predicted to enable BMP receptor binding activity; protein heterodimerization activity; and receptor ligand activity. Involved in several processes, including iron ion homeostasis; positive regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including endochondral ossification; male genitalia development; and osteoblast differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; female reproductive system; sensory organ; and skeleton. Orthologous to human BMP6 (bone morphogenetic protein 6).

大鼠 Rat Bmp6 分子靶点信息

大鼠 Rat Bmp6 靶点分子功能（预测）

Enables growth factor activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of aldosterone secretion; and positive regulation of cell differentiation. Located in cytoplasm; extracellular space; and vesicle. Biomarker of anemia; brain ischemia; and colitis. Orthologous to human BMP6 (bone morphogenetic protein 6).

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