BCL2 靶点信息

BCL2 分子靶点信息概述

  • 分子名：BCL2, BCL2 apoptosis regulator
  • 基因家族：Protein phosphatase 1 regulatory subunits; BCL2 family
  • 别名：Bcl-2; PPP1R50
  • 全称：protein phosphatase 1, regulatory subunit 50; B-cell CLL/lymphoma 2; BCL2, apoptosis regulator

BCL2 分子靶点综述

B细胞淋巴瘤2 (Bcl-2)，是Bcl-2家族调节蛋白中的创始成员，可通过诱导凋亡(促凋亡)或者抑制凋亡(抗凋亡)来调节细胞凋亡。Bcl-2已明确是一种重要的抗凋亡蛋白，因此被归类为是一种致癌基因。Bcl-2调节线粒体动力学，并参与线粒体融合与分裂的调控。另外，在胰岛β细胞中，Bcl-2和Bcl-XL参与控制代谢活性和胰岛素分泌。 Bcl-2基因损伤会引发许多癌症，包括黑色素瘤、乳腺癌、前列腺癌、慢性淋巴细胞白血病和肺癌，还可能与精神分裂症和自身免疫性疾病有关。Bcl-2也是癌症治疗抵抗的一个原因。

BCL2, BCL2 apoptosis regulator 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human BCL2 分子靶点信息

  • 分子名：BCL2, BCL2 apoptosis regulator
  • 别称：
    • apoptosis regulator Bcl-2
    • B-cell CLL/lymphoma 2
    • b-cell leukemia/lymphoma 2
    • Bcl-2
    • Bcl-2a
    • Bcl-2?
    • BCL2, apoptosis regulator
    • PPP1R50
    • protein phosphatase 1, regulatory subunit 50
  • 基因序列：NCBI_Gene: 596
  • 蛋白序列：UniProtKB: P10415

人 Human BCL2靶点分子功能（预测）

Enables several functions, including BH3 domain binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including B cell receptor signaling pathway; negative regulation of apoptotic process; and positive regulation of B cell proliferation. Acts upstream of or within several processes, including B cell proliferation; apoptotic signaling pathway; and negative regulation of apoptotic process. Located in endoplasmic reticulum; mitochondrial outer membrane; and nucleus. Part of pore complex. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Biomarker of several diseases, including cervix uteri carcinoma in situ; ductal carcinoma in situ; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and urinary system cancer (multiple).

小鼠 Mouse Bcl2 分子靶点信息

小鼠 Mouse Bcl2 靶点分子功能（预测）

Enables protein phosphatase 2A binding activity. Involved in several processes, including hair follicle morphogenesis; mitochondrion organization; and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and negative regulation of programmed cell death. Located in several cellular components, including mitochondrial membrane; myelin sheath; and nuclear membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Used to study oligomeganephronia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).

大鼠 Rat Bcl2 分子靶点信息

大鼠 Rat Bcl2 靶点分子功能（预测）

Enables BH domain binding activity. Involved in several processes, including response to peptide; response to purine-containing compound; and response to vitamin. Located in cytosol; mitochondrial crista; and perinuclear region of cytoplasm. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; gastric ulcer; intestinal disease (multiple); and status epilepticus. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain disease (multiple); hypertension (multiple); intrinsic cardiomyopathy (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).

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