ANPEP 靶点信息

ANPEP 分子靶点信息概述

  • 分子名：ANPEP, alanyl aminopeptidase, membrane
  • 基因家族：Aminopeptidases; CD molecules; M1 metallopeptidases
  • 别名：LAP1; gp150; p150
  • 曾用名：CD13; PEPN
  • 全称：aminopeptidase N; aminopeptidase M; microsomal aminopeptidase; membrane alanyl aminopeptidase; alanyl (membrane) aminopeptidase

ANPEP 分子靶点综述

CD13 也被称为氨基酸肽 N，是金属蛋白酶膜整合素Ⅱ型中的一个成员。CD13 为冠状病毒的受体，冠状病毒在人类和几种动物种属中能够引起呼吸道疾病。CD13 的功能作为一种锌结合金属蛋白酶在细胞表面抗原表达中通过 MHC 分类Ⅱ结合肽修整 N-末端氨基酸而发挥作用。CD13 表达在粒细胞、单核细胞与它们的前体细胞，以及大多数急性髓系白血病和小部分急性淋巴细胞白血病中。在非造血细胞中 CD13 表达在包括上皮细胞、肾近曲小管、肠刷状缘、内皮细胞、纤维母细胞、脑细胞、骨髓、破骨细胞和胆管内层细胞。

ANPEP, alanyl aminopeptidase, membrane 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ANPEP 分子靶点信息

  • 分子名：ANPEP, alanyl aminopeptidase, membrane
  • 别称：
    • alanyl (membrane) aminopeptidase
    • alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)
    • alanyl aminopeptidase
    • aminopeptidase M
    • aminopeptidase N
    • AP-M
    • AP-N
    • APN
    • CD13
    • GP150
    • hAPN
    • LAP1
    • membrane alanyl aminopeptidase
    • microsomal aminopeptidase
    • myeloid plasma membrane glycoprotein CD13
    • P150
    • PEPN
  • 基因序列：NCBI_Gene: 290
  • 蛋白序列：UniProtKB: P15144

人 Human ANPEP靶点分子功能（预测）

Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Located in endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; and plasma membrane. Biomarker of severe acute respiratory syndrome.

小鼠 Mouse Anpep 分子靶点信息

小鼠 Mouse Anpep 靶点分子功能（预测）

Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of renal sodium excretion; peptide catabolic process; and proteolysis. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and sensory organ. Orthologous to human ANPEP (alanyl aminopeptidase, membrane).

大鼠 Rat Anpep 分子靶点信息

  • 分子名：Anpep, alanyl aminopeptidase, membrane
  • 别称：
    • alanyl (membrane) aminopeptidase
    • alanyl aminopeptidase
    • aminopeptidase M
    • aminopeptidase N
    • AP-M
    • AP-N
    • Apm
    • APN
    • cluster of differentiation antigen 13 (CD13)
    • kidney aminopeptidase M
    • kidney Zn peptidase
    • KZP
    • Lap1
    • leucine arylaminopeptidase 1
    • membrane alanine aminopeptidase
    • microsomal aminopeptidase
    • rAPN
  • 基因序列：NCBI_Gene: 81641
  • 蛋白序列：

大鼠 Rat Anpep 靶点分子功能（预测）

Enables aminopeptidase activity and peptide binding activity. Involved in negative regulation of renal sodium excretion; peptide catabolic process; and proteolysis. Located in brush border membrane. Orthologous to human ANPEP (alanyl aminopeptidase, membrane).

ANPEP 分子产品列表

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