TREM2 靶点信息

TREM2 分子靶点信息概述

  • 分子名：TREM2, triggering receptor expressed on myeloid cells 2
  • 基因家族：V-set domain containing
  • 别名：TREM-2; Trem2a; Trem2b; Trem2c
  • 全称：triggering receptor expressed on myeloid cells 2a

TREM2 分子靶点综述

髓系细胞触发受体2 (TREM2)是一个单一Ig结构域受体，它在巨噬细胞和树突状细胞中表达，但不在粒细胞或单核细胞中表达。它在基底节、胼胝体、延髓和脊髓中的表达最丰富，而中枢神经系统中的小胶质细胞是产生TREM2的最主要的细胞类型。TREM2在慢性炎症中发挥作用，可刺激组成的而非炎症的趋化因子和细胞因子产生。TREM2与TYROBP组成受体信号复合物来激活巨噬细胞和树突状细胞的免疫应答。它同样与衔接蛋白DAP12联系在一起来传递活化信号，该信号在先天性和适应性免疫应答中起作用。TREM2信号也是一个促进结肠伤口愈合的重要途径。TREM2突变会增加神经退行性疾病如阿尔茨海默氏病、肌萎缩侧索硬化症和帕金森氏病的风险。

TREM2, triggering receptor expressed on myeloid cells 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TREM2 分子靶点信息

  • 分子名：TREM2, triggering receptor expressed on myeloid cells 2
  • 别称：
    • PLOSL2
    • TREM-2
    • Trem2a
    • Trem2b
    • Trem2c
    • triggering receptor expressed on monocytes 2
    • triggering receptor expressed on myeloid cells 2a
  • 基因序列：NCBI_Gene: 54209
  • 蛋白序列：UniProtKB: Q9NZC2

人 Human TREM2靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in several processes, including positive regulation of protein localization; positive regulation of signal transduction; and regulation of neuroinflammatory response. Acts upstream of with a positive effect on memory and social behavior. Acts upstream of or within with a positive effect on CXCL12-activated CXCR4 signaling pathway. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; osteoclast differentiation; and positive regulation of macromolecule metabolic process. Located in plasma membrane. Is integral component of membrane and intrinsic component of plasma membrane. Part of plasma membrane raft. Biomarker of syphilis.

小鼠 Mouse Trem2 分子靶点信息

  • 分子名：Trem2, triggering receptor expressed on myeloid cells 2
  • 别称：
    • Trem2a
    • Trem2b
    • Trem2c
    • triggering receptor expressed on myeloid cells 2a
    • triggering receptor expressed on myeloid cells 2b
    • triggering receptor expressed on myeloid cells 2c
  • 基因序列：NCBI_Gene: 83433
  • 蛋白序列：

小鼠 Mouse Trem2 靶点分子功能（预测）

Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Acts upstream of or within with a positive effect on defense response to Gram-negative bacterium. Acts upstream of or within with a negative effect on pyroptosis. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and social behavior. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in central nervous system; embryo mesenchyme; genitourinary system; and limb interdigital region. Used to study frontotemporal dementia. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).

大鼠 Rat Trem2 分子靶点信息

大鼠 Rat Trem2 靶点分子功能（预测）

Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).

TREM2 分子产品列表

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