IL17F 靶点信息

IL17F 分子靶点信息概述

  • 分子名：IL17F, interleukin 17F
  • 基因家族：Interleukins
  • 别名：IL-17F; ML-1; ML1

IL17F 分子靶点综述

白细胞介素17F(IL-17F)和IL-17A是IL-17家族中紧密相关的两个成员，有大约50%氨基酸同源。IL-17F来源于不同细胞类型，如Th17细胞、肥大细胞和嗜碱性粒细胞，在组织中广泛表达，包括肺。IL-17F可诱导支气管上皮细胞、血管内皮细胞、成纤维细胞和嗜酸性粒细胞中的许多细胞因子、趋化因子和粘附分子。IL-17F利用IL-17RA和IL-17RC作为其受体，激活MAP激酶相关通路。小鼠气道IL-17F基因的过表达与气道中的中性粒细胞增多、多种细胞因子的诱导、气道高反应性和粘液高分泌增加有关。因此，IL-17F在过敏性气道炎症中可能起到重要作用，对哮喘有重要的治疗意义。

IL17F, interleukin 17F 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL17F 分子靶点信息

  • 分子名：IL17F, interleukin 17F
  • 别称：
    • CANDF6
    • cytokine ML-1
    • IL-17F
    • IL-24
    • interleukin-17F
    • interleukin-24
    • ML-1
    • ML1
    • mutant IL-17F
  • 基因序列：NCBI_Gene: 112744
  • 蛋白序列：UniProtKB: Q96PD4

人 Human IL17F靶点分子功能（预测）

Enables cytokine activity; cytokine binding activity; and protein homodimerization activity. Involved in several processes, including interleukin-17-mediated signaling pathway; negative regulation of angiogenesis; and regulation of cytokine production. Predicted to be located in extracellular region. Implicated in chronic mucocutaneous candidiasis.

小鼠 Mouse Il17f 分子靶点信息

小鼠 Mouse Il17f 靶点分子功能（预测）

Enables cytokine receptor binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in defense response to bacterium and positive regulation of gene expression. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F).

大鼠 Rat Il17f 分子靶点信息

大鼠 Rat Il17f 靶点分子功能（预测）

Predicted to enable cytokine binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to bacterium; interleukin-17-mediated signaling pathway; and regulation of cytokine production. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F).

IL17F 分子产品列表

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