ADIPOQ 靶点信息

ADIPOQ 分子靶点信息概述

  • 分子名：ADIPOQ, adiponectin, C1Q and collagen domain containing
  • 基因家族：C1q and TNF related
  • 别名：ACRP30; apM1; GBP28; adiponectin
  • 曾用名：ACDC
  • 全称：adipose most abundant gene transcript 1; adiponectin precursor; adipocyte, C1Q and collagen domain containing

ADIPOQ 分子靶点综述

脂联素，又称脂肪细胞补体相关蛋白30(Acrp30)，参与调节葡萄糖水平和脂肪酸分解。它组装成不同的复合物包括三聚体、六聚体和高阶寡聚体结构，进而可能影响生物活性。脂联素是一种蛋白质激素，调节许多代谢过程，包括葡萄糖调节和脂肪酸氧化。脂肪组织(以及妊娠期的胎盘)专门分泌脂联素到血液中，因此相对于其它许多激素，血浆中的脂联素含量很丰富。脂联素可能具有抗动脉粥样硬化和消炎的作用，可负向调节粒单祖细胞的生长和TNF-α在巨噬细胞中的产生。监测一些病理状态下的血清脂联素水平，如2型糖尿病、肥胖、动脉粥样硬化和非酒精性脂肪肝疾病，可为我们了解脂联素提供更详细的见解。

ADIPOQ, adiponectin, C1Q and collagen domain containing 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ADIPOQ 分子靶点信息

  • 分子名：ADIPOQ, adiponectin, C1Q and collagen domain containing
  • 别称：
    • 30 kDa adipocyte complement-related protein
    • ACDC
    • ACRP30
    • adipocyte complement-related 30 kDa protein
    • adiponectin
    • adipose most abundant gene transcript 1 protein
    • adipose specific collagen-like factor
    • ADIPQTL1
    • ADPN
    • APM-1
    • APM1
    • GBP28
    • gelatin-binding protein 28
  • 基因序列：NCBI_Gene: 9370
  • 蛋白序列：UniProtKB: Q15848

人 Human ADIPOQ靶点分子功能（预测）

Enables hormone activity; protein homodimerization activity; and sialic acid binding activity. Involved in several processes, including negative regulation of cell communication; negative regulation of cell differentiation; and negative regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Part of collagen-containing extracellular matrix. Implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); and inflammatory bowel disease (multiple).

小鼠 Mouse Adipoq 分子靶点信息

小鼠 Mouse Adipoq 靶点分子功能（预测）

Enables hormone activity and identical protein binding activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; negative regulation of gluconeogenesis; and positive regulation of glucose import. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; axial musculature; gut; male reproductive gland or organ; and serum. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing).

大鼠 Rat Adipoq 分子靶点信息

大鼠 Rat Adipoq 靶点分子功能（预测）

Enables identical protein binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of glycogen (starch) synthase activity; and positive regulation of protein phosphorylation. Located in extracellular space. Part of protein-containing complex. Used to study brain infarction. Biomarker of several diseases, including end stage renal disease; fatty liver disease (multiple); glucose metabolism disease (multiple); hyperthyroidism; and obesity. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing).

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