TIMP3 靶点信息

TIMP3 分子靶点信息概述

  • 分子名：TIMP3, TIMP metallopeptidase inhibitor 3
  • 基因家族：Tissue inhibitor of metallopeptidases
  • 曾用名：SFD
  • 全称：tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)

TIMP3 分子靶点综述

组织金属蛋白酶抑制剂3 (TIMP-3)是人体内由TIMP3基因编码的一种蛋白质，属于金属蛋白酶基因家族的组织抑制剂。该家族有四个成员：TIMP-1、TIMP-2、TIMP-3和TIMP-4。TIMP-3是由很多类型的细胞分泌产生的分子量为30 kDa的糖蛋白。TIMP-3通过其N末端结构域与MMP活性位点形成非共价二元复合物，来抑制活性MMP介导的蛋白水解。此外，TIMP-3也是炎症因子抑制剂，负向调控TACE，促进TNF-α的释放，反过来引起机体发生炎症反应和血管重塑。该基因突变与常染色体显性遗传性Sorsby眼底营养不良有关。

TIMP3, TIMP metallopeptidase inhibitor 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TIMP3 分子靶点信息

  • 分子名：TIMP3, TIMP metallopeptidase inhibitor 3
  • 别称：
    • HSMRK222
    • K222
    • K222TA2
    • metalloproteinase inhibitor 3
    • MIG-5 protein
    • protein MIG-5
    • SFD
    • TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    • TIMP-3
    • tissue inhibitor of metalloproteinase 3
    • tissue inhibitor of metalloproteinases 3
  • 基因序列：NCBI_Gene: 7078
  • 蛋白序列：UniProtKB: P35625

人 Human TIMP3靶点分子功能（预测）

Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of TRAIL-activated apoptotic signaling pathway. Located in nucleus. Colocalizes with collagen-containing extracellular matrix. Implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Biomarker of several diseases, including breast cancer (multiple); preretinal fibrosis; reproductive organ cancer (multiple); thoracic aortic aneurysm; and type 2 diabetes mellitus.

小鼠 Mouse Timp3 分子靶点信息

小鼠 Mouse Timp3 靶点分子功能（预测）

Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of metalloendopeptidase activity. Acts upstream of or within cellular response to organic substance. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).

大鼠 Rat Timp3 分子靶点信息

  • 分子名：Timp3, TIMP metallopeptidase inhibitor 3
  • 别称：
    • metalloproteinase inhibitor 3
    • TIMP-3
    • tissue inhibitor of metalloproteinase 3
    • tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    • tissue inhibitor of metalloproteinases 3
  • 基因序列：NCBI_Gene: 25358
  • 蛋白序列：

大鼠 Rat Timp3 靶点分子功能（预测）

Predicted to enable metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of proteolysis; response to estrogen; and response to folic acid. Located in cytoplasm. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).

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