SPP1 靶点信息

SPP1 分子靶点信息概述

  • 分子名：SPP1, secreted phosphoprotein 1
  • 基因家族：Receptor ligands; SIBLING family
  • 别名：BSPI; ETA-1
  • 曾用名：BNSP; OPN
  • 全称：early T-lymphocyte activation 1; osteopontin; bone sialoprotein I

SPP1 分子靶点综述

骨桥蛋白(OPN)，又名BSP-1、ETA-1、SPP-1或Ric，在人类中由SPP1基因编码，主要在骨骼中表达。OPN基因的调节机制还未完全阐明，不同细胞类型的调节机理是不同的。OPN在生物矿化、骨重塑、免疫功能、趋化、细胞活化和凋亡上有作用，同样与心肌细胞凋亡和心肌功能紊乱的增加有关。OPN与许多生理和病理过程包括伤口愈合、骨转换、肿瘤发生、炎症、缺血和免疫应答有关。调控血浆(或局部)的OPN水平对治疗自身免疫性疾病、癌症转移、骨和牙齿的矿化、骨质疏松症和一些应激形式有帮助。

SPP1, secreted phosphoprotein 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SPP1 分子靶点信息

  • 分子名：SPP1, secreted phosphoprotein 1
  • 别称：
    • BNSP
    • bone sialoprotein 1
    • bone sialoprotein I
    • BSPI
    • early T-lymphocyte activation 1
    • ETA-1
    • MGC110940
    • nephropontin
    • OPN
    • osteopontin
    • osteopontin-C
    • osteopontin-D
    • osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
    • secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
    • secreted phosphoprotein 1 variant 6
    • secreted phosphoprotein-1 (osteopontin, bone sialoprotein)
    • SPP-1
    • SPP1/CALPHA1 fusion
    • urinary stone protein
    • uropontin
  • 基因序列：NCBI_Gene: 6696
  • 蛋白序列：UniProtKB: P10451

人 Human SPP1靶点分子功能（预测）

Enables integrin binding activity. Involved in several processes, including androgen catabolic process; cellular response to testosterone stimulus; and positive regulation of estradiol secretion. Located in Golgi apparatus and extracellular space. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Biomarker of calcinosis; coronary artery disease; kidney failure; progressive osseous heteroplasia; and urinary bladder cancer.

小鼠 Mouse Spp1 分子靶点信息

小鼠 Mouse Spp1 靶点分子功能（预测）

Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).

大鼠 Rat Spp1 分子靶点信息

  • 分子名：Spp1, secreted phosphoprotein 1
  • 别称：
    • bone sialoprotein 1
    • LOC100359743
    • OSP
    • osteopontin
    • osteopontin-like
    • Sialoprotein (osteopontin)
    • SPP-1
  • 基因序列：NCBI_Gene: 25353
  • 蛋白序列：UniProtKB: P08721

大鼠 Rat Spp1 靶点分子功能（预测）

Predicted to enable extracellular matrix binding activity and integrin binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; osteoblast differentiation; and positive regulation of bone resorption. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).

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