CCL22 靶点信息

CCL22 分子靶点信息概述

  • 分子名：CCL22, C-C motif chemokine ligand 22
  • 基因家族：Chemokine ligands
  • 别名：MDC; STCP-1; ABCD-1; DC/B-CK; A-152E5.1; MGC34554
  • 曾用名：SCYA22
  • 全称：small inducible cytokine subfamily A (Cys-Cys), member 22; chemokine (C-C motif) ligand 22

CCL22 分子靶点综述

趋化因子配体22 (CCL22)，又名巨噬细胞来源的趋化因子(MDC)，是CC趋化因子家族中的一员。B细胞、小胶质细胞、树突状细胞、巨噬细胞、单核细胞、干扰素γ激活的角质细胞、结肠上皮细胞、CD4+ T细胞、胸腺髓质上皮细胞(小体)和活化的NK细胞都可表达CCL22。 CCL22对淋巴细胞迁移有重要作用，它是树突状细胞、胸腺细胞和活化的NK细胞等细胞类型的有效趋化物。抗原递呈树突状细胞产生的CCL22趋化携有CCR4的活化 (或记忆)T细胞，从而增强机体的免疫应答，增加效应功能。CCL22还有其他功能，包括血小板功能的激活、抑制海马神经元之间的突触传递。

CCL22, C-C motif chemokine ligand 22 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCL22 分子靶点信息

  • 分子名：CCL22, C-C motif chemokine ligand 22
  • 别称：
    • A-152E5.1
    • ABCD-1
    • C-C motif chemokine 22
    • CC chemokine STCP-1
    • chemokine (C-C motif) ligand 22
    • DC/B-CK
    • macrophage-derived chemokine
    • MDC
    • MDC(1-69)
    • MGC34554
    • SCYA22
    • small inducible cytokine A22
    • small inducible cytokine subfamily A (Cys-Cys), member 22
    • small-inducible cytokine A22
    • STCP-1
    • stimulated T cell chemotactic protein 1
    • stimulated T-cell chemotactic protein 1
  • 基因序列：NCBI_Gene: 6367
  • 蛋白序列：UniProtKB: O00626

人 Human CCL22靶点分子功能（预测）

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including arthritis (multiple); cervical squamous cell carcinoma; lung disease (multiple); pleural tuberculosis; and rhinitis.

小鼠 Mouse Ccl22 分子靶点信息

小鼠 Mouse Ccl22 靶点分子功能（预测）

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within chemotaxis. Located in extracellular space. Is expressed in inguinal lymph node; thymus; and thymus primordium. Orthologous to human CCL22 (C-C motif chemokine ligand 22).

大鼠 Rat Ccl22 分子靶点信息

  • 分子名：Ccl22, C-C motif chemokine ligand 22
  • 别称：
    • C-C motif chemokine 22
    • chemokine (C-C motif) ligand 22
    • Mdc
    • MGC108943
    • Scya22
    • small inducible cytokine A22
    • small inducible cytokine subfamily A (Cys-Cys) member 22
    • small inducible cytokine subfamily A (Cys-Cys), member 22
  • 基因序列：NCBI_Gene: 117551
  • 蛋白序列：UniProtKB: Q5I0L5

大鼠 Rat Ccl22 靶点分子功能（预测）

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in extracellular space. Used to study anti-basement membrane glomerulonephritis. Biomarker of asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL22 (C-C motif chemokine ligand 22).

CCL22 分子产品列表

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