CCL18 靶点信息

CCL18 分子靶点信息概述

  • 分子名：CCL18, C-C motif chemokine ligand 18
  • 基因家族：Chemokine ligands
  • 别名：DC-CK1; PARC; AMAC-1; DCCK1; MIP-4; CKb7
  • 曾用名：SCYA18
  • 全称：pulmonary and activation-regulated; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated); chemokine (C-C motif) ligand 18

CCL18 分子靶点综述

趋化因子CC配体18(CCL18)也称为肺及活化调节趋化因子(PARC)，主要由先天免疫系统中的抗原递呈细胞产生，包括树突细胞、单核细胞和巨噬细胞。CCL18参与吸引幼稚T细胞、调节性T细胞、Th2细胞、免疫抑制性和未成熟树突细胞、嗜碱性粒细胞以及幼稚和效应B细胞。在很多疾病中可观察到CCL18的异常表达，包括乳腺癌、自身免疫疾病和过敏，被认为CCL18异常表达在这些疾病进程中发挥作用。

CCL18, C-C motif chemokine ligand 18 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCL18 分子靶点信息

  • 分子名：CCL18, C-C motif chemokine ligand 18
  • 别称：
    • alternative macrophage activation-associated CC chemokine 1
    • AMAC-1
    • AMAC1
    • C-C motif chemokine 18
    • CC chemokine ligand 18
    • CC chemokine PARC
    • chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
    • chemokine (C-C), dendritic
    • CKb7
    • DC-CK1
    • DCCK1
    • dendritic cell chemokine 1
    • macrophage inflammatory protein 4
    • MIP-4
    • PARC
    • pulmonary and activation-regulated chemokine
    • SCYA18
    • small inducible cytokine A18
    • small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
    • small-inducible cytokine A18
  • 基因序列：NCBI_Gene: 6362
  • 蛋白序列：UniProtKB: P55774

人 Human CCL18靶点分子功能（预测）

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be active in extracellular space.

小鼠 Mouse Ccl3 分子靶点信息

小鼠 Mouse Ccl3 靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including astrocyte cell migration; macrophage chemotaxis; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in articular cartilage; cartilage; knee joint; lung; and radius. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3).

CCL18 分子产品列表

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