NRP2 靶点信息

NRP2 分子靶点信息概述

  • 分子名：NRP2, neuropilin 2
  • 别名：VEGF165R2

NRP2 分子靶点综述

神经纤毛蛋白-2(NRP2)在人类中由NRP2基因编码，编码产物是受体蛋白中神经纤毛蛋白家族的成员。该跨膜蛋白与SEMA3C和SEMA3F蛋白结合，与血管生长因子(VEGF)发生相互作用。NRP2在心血管发育、轴突导向和肿瘤发生中发挥作用。该基因还有多种转录本变异，编码不同的亚型。

NRP2, neuropilin 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NRP2 分子靶点信息

  • 分子名：NRP2, neuropilin 2
  • 别称：
    • MGC126574
    • neuropilin-2
    • neuropilin-2a(17)
    • neuropilin-2a(22)
    • neuropilin-2b(0)
    • NP2
    • NPN2
    • PRO2714
    • receptor for VEGF165 and semaphorins class3
    • vascular endothelial cell growth factor 165 receptor 2
    • vascular endothelial growth factor-165 receptor 2
    • VEGF165R2
  • 基因序列：NCBI_Gene: 8828
  • 蛋白序列：UniProtKB: O60462

人 Human NRP2靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in nervous system development and outflow tract septum morphogenesis. Predicted to act upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and neural crest cell migration. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic membrane.

小鼠 Mouse Nrp2 分子靶点信息

小鼠 Mouse Nrp2 靶点分子功能（预测）

Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and neural crest cell migration. Located in axon. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and limb. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2).

大鼠 Rat Nrp2 分子靶点信息

  • 分子名：Nrp2, neuropilin 2
  • 别称：
    • neuropilin-2
    • vascular endothelial cell growth factor 165 receptor 2
  • 基因序列：NCBI_Gene: 81527
  • 蛋白序列：UniProtKB: O35276

大鼠 Rat Nrp2 靶点分子功能（预测）

Predicted to enable identical protein binding activity and semaphorin receptor activity. Involved in axon guidance. Predicted to be located in axon. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic membrane. Orthologous to human NRP2 (neuropilin 2).

NRP2 分子产品列表

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