NRG1 靶点信息

NRG1 分子靶点信息概述

  • 分子名：NRG1, neuregulin 1
  • 基因家族：I-set domain containing; Neuregulins
  • 别名：HRG; NDF; GGF
  • 曾用名：HGL; NRG1-IT2
  • 全称：NRG1 intronic transcript 2 (non-protein coding)

NRG1 分子靶点综述

神经调节蛋白1 (NRG1)最初被鉴定为是一个44 kD的糖蛋白，它能与NEU/ERBB2受体酪氨酸激酶相互作用，以此增加酪氨酸残基的磷酸化。从NRG1基因通过选择性剪接产生了各种不同的异构体。这些亚型包括heregulins (HRGs)、神经生长因子(GGFS)、感觉和运动神经元衍生因子(SMDF)。神经调节蛋白和它的各种亚型都来自一个四个结构相关的蛋白质家族，它们是EGF蛋白家族的一部分。这些蛋白质不仅在神经系统发育过程中发挥着多种作用还在脊椎动物胚胎发育(包括心脏发育、神经膜细胞和少突胶质细胞分化、神经发育的某些方面以及神经肌肉突触的形成)的过程中发挥多重作用。

NRG1, neuregulin 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NRG1 分子靶点信息

  • 分子名：NRG1, neuregulin 1
  • 别称：
    • acetylcholine receptor-inducing activity
    • ARIA
    • GGF
    • GGF2
    • glial growth factor
    • glial growth factor 2
    • heregulin, alpha (45kD, ERBB2 p185-activator)
    • HGL
    • HRG
    • HRG1
    • HRGA
    • MST131
    • MSTP131
    • NDF
    • neu differentiation factor
    • neuregulin 1 type IV beta 1a
    • neuregulin 1 type IV beta 3
    • NRG1 intronic transcript 2 (non-protein coding)
    • NRG1-IT2
    • pro-neuregulin-1, membrane-bound isoform
    • pro-NRG1
    • sensory and motor neuron derived factor
    • SMDF
  • 基因序列：NCBI_Gene: 3084
  • 蛋白序列：UniProtKB: Q02297

人 Human NRG1靶点分子功能（预测）

Enables protein tyrosine kinase activator activity; signaling receptor binding activity; and transcription coregulator activity. Involved in several processes, including ERBB signaling pathway; heart development; and positive regulation of protein phosphorylation. Acts upstream of or within cellular protein complex disassembly and negative regulation of transcription, DNA-templated. Located in apical plasma membrane; extracellular space; and nucleoplasm. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Biomarker of Alzheimer's disease; hepatocellular carcinoma; major depressive disorder; and ovarian cancer.

小鼠 Mouse Nrg1 分子靶点信息

小鼠 Mouse Nrg1 靶点分子功能（预测）

Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including positive regulation of cardiac muscle cell differentiation; postsynapse to nucleus signaling pathway; and synapse assembly. Acts upstream of or within several processes, including neurogenesis; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axolemma; external side of plasma membrane; and neuromuscular junction. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).

大鼠 Rat Nrg1 分子靶点信息

大鼠 Rat Nrg1 靶点分子功能（预测）

Enables receptor tyrosine kinase binding activity. Involved in several processes, including negative regulation of corticosterone secretion; positive regulation of Schwann cell proliferation; and response to progesterone. Located in extracellular space and synapse. Used to study sciatic neuropathy. Biomarker of diabetic neuropathy; median neuropathy; schizophrenia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).

NRG1 分子产品列表

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